diff --git a/lodash.js b/lodash.js
index 95ce9399e..8c56c3a83 100644
--- a/lodash.js
+++ b/lodash.js
@@ -11434,7 +11434,7 @@
         return !value.size;
       }
       if (isPrototype(value)) {
-        return !nativeKeys(value).length;
+        return !baseKeys(value).length;
       }
       for (var key in value) {
         if (hasOwnProperty.call(value, key)) {
diff --git a/test/test.js b/test/test.js
index 7b6595197..eaf3e6c4d 100644
--- a/test/test.js
+++ b/test/test.js
@@ -9366,6 +9366,18 @@
       assert.strictEqual(_.isEmpty(args), false);
     });
 
+    QUnit.test('should work with prototytpe objects', function(assert) {
+      assert.expect(2);
+
+      function Foo() {}
+      Foo.prototype = { 'constructor': Foo };
+
+      assert.strictEqual(_.isEmpty(Foo.prototype), true);
+
+      Foo.prototype.a = 1;
+      assert.strictEqual(_.isEmpty(Foo.prototype), false);
+    });
+
     QUnit.test('should work with jQuery/MooTools DOM query collections', function(assert) {
       assert.expect(1);